Scientific publications
Date: 2023. Group: Biomedical research
Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents.
Nagy, A., Szűcs, K. F., Grosz G., Süle, M., Fekete, F., Karoliny, A., Borsos, M., Papp, Z., Vigh, D., & Gáspár, R.
Heliyon, 9(8), e18859.
Date: 2023. Group: Biomedical research (in consortium with MDE Ltd.)
Combined uterorelaxant effect of magnesium sulfate and terbutaline: Studies on late pregnant rat uteri in vitro and in vivo.
Barna, T., Szucs, K. F., Schaffer, A., Mirdamadi, M., Hajagos‐Toth, J., & Gaspar, R.
Acta Obstetricia et Gynecologica Scandinavica, 102(4), 457-464.
Date: 2023. Group: Biomedical research (in consortium with MDE Ltd.)
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760.
Cacanyiova, S., Cebova, M., Simko, F., Baka, T., Bernatova, I., Kluknavsky, M., Zorad, S., Krskova, K., Shaman, E., Zemancikova, A., Barta, A., Aydemir, B. G., & Berenyiova, A.
Biological Research, 56(1).
Date: 2023. Group: Medical diagnostics (in consortium with MDE Ltd.)
A three-month physical training program improves cardiovascular autonomic function in patients with metabolic syndrome with and without diabetes – a pilot study.
Vágvölgyi, A., Ábrahám, J. E., Máthéné Köteles, É., Korom, A., Barnai, M., Szűcs, M., Orosz, A., Kempler, P., Menyhárt, A., Nemes, A., Várkonyi, T., Baczkó, I., Kósa, I., & Lengyel, C.
Frontiers in Endocrinology, 14.
Date: 2022. Group: Biomedical research (in consortium with MDE Ltd.)
Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study.
Mirdamadi, M., Schaffer, A., Barna, T., Samavati, R., Szűcs, K. F., Szűcs, E., Benyhe, S., Szécsi, M., & Gáspár, R.
European Journal of Pharmacology, 935, 175346.
Date: 2022. Group: Biomedical research (in consortium with MDE Ltd.)
The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
Schaffer, A., Ducza, E., Bódi, N., Bagyánszki, M., Szalai, Z., Mirdamadi, M., Barna, T., Szűcs, K. F., & Gáspár, R.
Life Sciences, 297, 120-465.
Date: 2022. Group: Biomedical research (previously: Experimetria Ltd.)
The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium.
Viczjan, G., Szilagyi, A., Takacs, B., Ovari, I., Szekeres, R., Tarjanyi, V., Erdei, T., Teleki, V., Zsuga, J., Szilvassy, Z., Juhasz, B., Varga, B., & Gesztelyi, R.
Frontiers in Pharmacology, 13.
Date: 2022. Group: Medical diagnostics (in consortium with MDE Ltd.)
Peripheral sensory and cardiovascular autonomic dysfunction in kidney transplant patients.
Vágvölgyi, A., Borda, B., Orosz, A., Szűcs, M., Nemes, A., Lázár, G., Baczkó, I., Kempler, P., Várkonyi, T., & Lengyel, C.
CEDA diabetes, 31(3), 175-184.
Date: 2021. Group: Biomedical research
Non-invasive smooth muscle electromyography (SMEMG) as a novel monitoring technology of the gastrointestinal tract of awake, free-moving pigs—A pilot study.
Nagy, K., Fébel, H., Bazar, G., Grosz, G., Gáspár, R., Ferenc Szűcs, K., & Tóth, T.
PLOS ONE, 16(9), e0257311.
Date: 2021. Group: Biomedical research (in consortium with MDE Ltd.)
Detection of acute stress by smooth muscle electromyography: A translational study on rat and human.
Pribék, I. K., Szűcs, K. F., Süle, M., Grosz, G., Ducza, E., Vigh, D., Tóth, E., Janka, Z., Kálmán, J., Datki, Z. L., Gáspár, R., & Andó, B.
Life Sciences, 277, 119492.
Date: 2021. Group: Biomedical research (in consortium with MDE Ltd.)
The ontogeny of kisspeptin receptor in the uterine contractions in rats: Its possible role in the quiescence of non-pregnant and pregnant uteri.
Schaffer, A., Hajagos-Tóth, J., Ducza, E., Bódi, N., Bagyánszki, M., Szalai, Z., & Gáspár, R.
European Journal of Pharmacology, 896, 173924.
Date: 2021. Group: Biomedical research (previously: Experimetria Kft.)
Angiotensin II-induced cardiac effects are modulated by endocannabinoid-mediated CB1 receptor activation.
Miklós, Z., Wafa, D., Nádasy, G. L., Tóth, Z. E., Besztercei, B., Dörnyei, G., Laska, Z., Benyó, Z., Ivanics, T., Hunyady, L., & Szekeres, M.
Cells, 10(4), 724.
Date: 2021. Group: Biomedical research (previously: Experimetria Ltd.)
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model.
Salinger-Martinovic, S., Cosic, V., Stojiljkovic, N., Ilic, S., Stojanovic, N., & Dencic, T.
Canadian Journal of Physiology and Pharmacology, 99(2), 185-191.
Date: 2021. Group: Medical diagnostics (in consortium with MDE Ltd.)
Peripheral and autonomic neuropathy status of young patients with type 1 diabetes mellitus at the time of transition from pediatric care to adult-oriented diabetes care.
Vágvölgyi, A., Maróti, Á., Szűcs, M., Póczik, C., Urbán-Pap, D., Baczkó, I., Nemes, A., Csajbók, É., Sepp, K., Kempler, P., Orosz, A., Várkonyi, T., & Lengyel, C.
Frontiers in Endocrinology, 12.
Date: 2020. Group: Biomedical research (in consortium with MDE Ltd.)
Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term.
Mirdamadi, M., Kothencz, A., Szűcs, E., Benyhe, S., Szécsi, M., & Gáspár, R.
Life Sciences, 263, 118584.
Date: 2020. Group: Biomedical research (previously: Experimetria Ltd.)
Negative inotropic effect of BGP-15 on the human right atrial myocardium.
Lampé, N., Priksz, D., Erdei, T., Bombicz, M., Kiss, R., Varga, B., Zsuga, J., Szerafin, T., Csanádi, Z., Balla, G., Balla, J., Szilvássy, Z., Gesztelyi, R., & Juhász, B.
Journal of Clinical Medicine, 9(5), 14-34.
Date: 2018. Group: Biomedical research (in consortium with MDE Ltd.)
Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats.
Szűcs, K., Grosz, G., Süle, M., Sztojkov-Ivanov, A., Ducza, E., Márki, A., Kothencz, A., Balogh, L., & Gáspár, R.
Life Sciences, 205, 1-8.
Date: 2017. Group: Biomedical research (in consortium with MDE Ltd.)
Identification of myoelectric signals of pregnant rat uterus: New method to detect myometrial contraction.
Szűcs, K. F., Grosz, G., Süle, M., Nagy, A., Tiszai, Z., Samavati, R., & Gáspár, R.
Croatian Medical Journal, 58(2), 141-148.
Date: 2016. Group: Biomedical research (in consortium with MDE Ltd.)
Correlation between slow-wave myoelectric signals and mechanical contractions in the gastrointestinal tract: Advanced electromyographic method in rats.
Szűcs, K. F., Nagy, A., Grosz, G., Tiszai, Z., & Gáspár, R.
Journal of Pharmacological and Toxicological Methods, 82, 37-44.
Date: 2016. Group: Medical diagnostics (in consortium with MDE Ltd.)
Why not to use the handgrip test in the assessment of cardiovascular autonomic neuropathy among patients with diabetes mellitus?
Körei, A., Kempler, M., Istenes, I., Vági, O., Putz, Z., Horváth, V., Keresztes, K., Lengyel, C., Tabák, Á., Spallone, V., & Kempler, P.
Current Vascular Pharmacology, 15(1), 66-73.
Date: 2015. Group: Medical diagnostics (in consortium with MDE Ltd.)
Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy.
Orosz, A., Baczkó, I., Nagy, V., Gavallér, H., Csanády, M., Forster, T., Papp, J. G., Varró, A., Lengyel, C., & Sepp, R.
Canadian Journal of Physiology and Pharmacology, 93(9), 765-772.
Date: 2015. Group: Medical diagnostics (previously: Experimetria Ltd.)
Increased short-term beat-to-beat variability of QT interval in patients with acromegaly.
Orosz, A., Csajbók, É., Czékus, C., Gavallér, H., Magony, S., Valkusz, Z., Várkonyi, T. T., Nemes, A., Baczkó, I., Forster, T., Wittmann, T., Papp, J. G., Varró, A., & Lengyel, C.
PLOS ONE, 10(4), e0125639.
Date: 2013. Group: Biomedical research (previously: Experimetria Ltd.)
Myocardial Postconditioning is lost in vascular nitrate tolerance.
Fekete, V., Murlasits, Z., Aypar, E., Bencsik, P., Sárközy, M., Szénási, G., Ferdinandy, P., & Csont, T.
Journal of Cardiovascular Pharmacology, 62(3), 298-303.
Date: 2012. Group: Biomedical research (previously: Experimetria Ltd.)
Dietary Phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis.
Kovács, T., Varga, G., Érces, D., Tőkés, T., Tiszlavicz, L., Ghyczy, M., Boros, M., & Kaszaki, J.
Shock, 38(2), 177-185.
Date: 2012. Group: Biomedical research (previously: Experimetria Ltd.)
N-methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats.
Érces, D., Varga, G., Fazekas, B., Kovács, T., Tőkés, T., Tiszlavicz, L., Fülöp, F., Vécsei, L., Boros, M., & Kaszaki, J.
European Journal of Pharmacology, 691(1-3), 225-234.
Date: 2011. Group: Medical diagnostics (previously Experimetria Ltd.)
Increased short-term variability of the QT interval in professional soccer players: Possible implications for arrhythmia prediction.
Lengyel, C., Orosz, A., Hegyi, P., Komka, Z., Udvardy, A., Bosnyák, E., Trájer, E., Pavlik, G., Tóth, M., Wittmann, T., Papp, J. G., Varró, A., & Baczkó, I.
PLoS ONE, 6(4), e18751.
Date: 2010. Group: Biomedical research (previously Experimetria Ltd.)
n-methyl-d-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
Varga, G., Érces, D., Fazekas, B., Fülöp, M., Kovács, T., Kaszaki, J., Fülöp, F., Vécsei, L., & Boros, M.
Neurogastroenterology & Motility, 22(2), 217-e68.
Date: 2007. Group: Biomedical research (previously Experimetria Ltd.)
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs.
Kaszaki, J., Palásthy, Z., Érczes, D., Rácz, A., Torday, C., Varga, G., Vécsei, L., & Boros, M.
Neurogastroenterology & Motility, 20(1), 53-62.
Date: 2006. Group: Biomedical research (previously Experimetria Ltd.)
Intestinal nitric oxide synthase activity changes during experimental colon obstruction.
Palásthy, Z., Kaszaki, J., Lázár, G., Nagy, S., & Boros, M.
Scandinavian Journal of Gastroenterology, 41(8), 910-918.
Date: 2005. Group: Biomedical research (previously Experimetria Ltd.)
Ischemia reperfusion injury of the skeletal muscle after selective deafferentation.
Turchányi, B., Tóth, B., Rácz, I., Vendégh, Z., Fűrész, J., & Hamar, J.
Physiological Research, 25-31.
Date: 2003. Group: Biomedical research (previously Experimetria Ltd.)
Thoracic epidural anesthesia improves the gastric microcirculation during experimental gastric tube formation.
Lázár, G., Kaszaki, J., Ábrahám, S., Horváth, G., Wolfárd, A., Szentpáli, K., Paszt, A., Balogh, Á., & Boros, M.
Surgery, 134(5), 799-805.
Date: 2003. Group: Biomedical research (previously Experimetria Ltd.)
Role of adrenergic receptor subtypes in the control of human placental blood vessels.
Resch, B. E., Ducza, E., Gáspár, R., & Falkay, G.
Molecular Reproduction and Development, 66(2), 166-171.
Date: 2002. Group: Biomedical research (previously Experimetria Ltd.)
Functional and histochemical characterization of a uterine adrenergic denervation process in pregnant rats.
Klukovits, A., Gáspár, R., Sántha, P., Jancsó, G., & Falkay, G.
Biology of Reproduction, 67(3), 1013-1017.
Projects and tenders
Date: 2019. Group: Medical diagnostics
G Development of a non-invasive complex measurement and evaluation system for the diagnosis of childhood reflux disease
Device: CPNSS/DB SS-DA
Location: Heim Pál Országos Gyermekgyógyászati Intézet
Contributed by: AdWare Research Ltd.
Project description:The aim of the project was to develop a prototype of a complex measurement tool and an integral diagnostic assessment module that would allow for the non-invasive diagnosis of childhood gastroesophageal reflux disease (GERD), following further development. Children with GERD may present with different symptoms and communication difficulties. The current invasive method of diagnosis is 24-hour pH measurement with a nasally inserted probe. The measurement interface of the prototype device developed was based on a measurement methodology that uses non-invasive sensors placed on the external surface of the abdomen to measure the myoelectric activity of the smooth muscle tissue of the gastrointestinal tract. During the development, the measured activities were recorded. This recorded recording is the so-called electrogastrogram (EGG). In order to use the EGG for diagnostic purposes, the development of objective evaluation modules and algorithms for the evaluation of the recorded signals was necessary to investigate the given disease type. Reflux events, in addition to changes in the EGG signals, also lead to changes in the ECG and its various parameters measured simultaneously, also non-invasively, due to the interaction between the gastric and cardiac regions under investigation. Analysing all these together suggests that a reliable diagnostic model for reflux can be established. As a result of this development, a clinical trial entitled “Clinical study for the diagnosis of childhood reflux disease by developing a non-invasive measurement and assessment method”, code number REFL_001/17, was conducted at Heim Pál Children’s Hospital using the combined (EGG,ECG) measurement and assessment tool of MSB-MET Ltd. 137 subjects were included in the study, of which data from 128 subjects can be included in the evaluation model. The mean age of the patients was 12.9±3.74 years, mean body weight was 48.99±18.213 kg, mean height 155.98±19.244 cm. Volunteers clinically diagnosed as reflux patients and non-reflux volunteers were included in the study. Volunteers diagnosed as refluxing underwent 24-hour esophageal pH measurement as part of their screening to confirm or reject the diagnosis, and thus the model building was performed in two groups, refluxing and non-refluxing volunteers. The results confirmed our expectations.
Source: https://heimpalkorhaz.hu/wp-content/uploads/2019/05/2ARGINOP219_05-reflux-sajtokozlemeny2ver.pdf
Date: 2021. Group: Biomedical research
A novel diagnostic approach and MSB-MET measurement system for monitoring physiological changes in complementary reproductive biology in livestock
Device: ME-01 In vivo myoelectrical (EGIG) measurement and evaluation system
Forums and conferences
Date: 2021. Group: Medical diagnostics
Sport Forum Hungary 2023
Device: CPNSS/DB SS-DA
Location: Puskás Ferenc Stadion, Budapest
Contributed by: Debreceni Egyetem
